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“That obtained us excited,” says Pangalos, who was eager to build up AstraZeneca’s pipeline of cardiovascular medicine. “It was extremely high danger. It was untried and untested.” But if it might work for one disease, it would doubtless work for many. Changing the illness goal didn’t require growing or identifying a whole new drug, simply altering the mRNA sequence. And although most of the initial animal studies used mRNAs with pseudouridine, Moderna’s new chemistry was already beginning to outperform that first generation in rodent studies. “I don’t assume it was such a stretch to imagine the expertise would continue to improve, given what they had been doing,” Pangalos says.
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Instead of getting shareholders and shares, it has guarantors and ensures. The guarantors’ …