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These efforts helped Grab hit $1 billion in revenue in 2018 and attract more than $3 billion in fresh funding to increase. Later this yr, it’ll add healthcare services from Ping An, the Chinese digital health big. Much of the chance comes right down to formulation—the molecular packaging that ferries mRNA into cells and protects it from being hacked apart by enzymes along the way in which. “That’s the place the breakthroughs are actually wanted,” says RaNA’s Heartlein. Many RNA drugs so far have encapsulated the nucleic acid in nanoparticles made from lipids. But as a result of mRNA is so giant—roughly a hundred occasions the size of the RNA used for interference therapies—it …
